RAF Typhoon FGR4s have operated alongside France's air force in a joint strike against an hidden munitions depot in Syrian territory operated by the Daesh militant organization, as stated by the British defence ministry.
The location, located using intelligence, was assessed as containing munitions and bombs, the statement said, and was located in mountainous terrain just above Palmyra in the heart of Syria.
"Our aircraft employed Paveway IV guided bombs to strike a series of access tunnels down to the facility... preliminary assessments indicate the strike was effective," the MoD said.
There was no sign of any civilian casualties in the strike conducted Saturday night and every plane involved returned safely, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
IS - alternatively referred to as the so-called Islamic State - established extremist governance over parts of Syria and Iraq until 2019.
"This operation shows the UK's leading role, and resolve to stand shoulder to shoulder with our allies, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief John Healey said.
British military aircraft have conducted patrols over Syrian airspace to "deter any attempted comeback" of Islamic State after its defeat at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to all the members of the UK armed forces participating in this strike for their professionalism and their courage," the Defence Secretary said. "They were part of numerous UK service members stationed over Christmas and New Year. This mission, to take out militants who endanger our way of life, demonstrates how British military are always on standby, throughout the year, protecting the UK within its borders and influential overseas."
Last December, the American forces carried out what it described as a "major assault" on IS targets in the country, after an ambush killed two American soldiers and a civilian interpreter in the Palmyra area.
The UN reports Daesh still has between 5,000 and 7,000 militants in Iraq and Syria.
