Fresh analysis reveals that patients who discontinue popular slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end conventional diet and exercise plans.
Findings released in a major health publication shows that while overweight individuals often shed about a fifth of their total mass while on the medication, the weight is regained at an average rate of 0.8 kg per month after stopping.
"People buying these medications should be aware of the risk of rapid weight regain when the treatment ends," stated researcher Dr. Susan Jebb.
That rate of regain implies a return to pre-treatment weight in about 18 months.
Analyzing Approaches
The study, which looked at 37 of trials involving thousands of patients, compared the effects of the injectable medications with other pills.
Researchers note that individuals who lose weight through dieting usually experience a less rapid creep back—approximately 0.1 kg a month—after stopping.
Explaining the Fast Regain
Experts suggest the mechanism of the drugs is key to understanding the accelerated regain.
The injections mimic a natural hormone called GLP-1, which controls appetite.
"Artificially providing GLP-1 concentrations several times higher than the body's typical production might result in the body to produce less of its own natural hormone, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication results in hunger is no longer kept in check, making binge eating a significant risk."
A Lifelong Condition?
Medical guidelines recommend the jabs for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
Professionals argue that, given the likelihood of relapse, the therapy might need to be long-term.
This opinion is supported by pharmaceutical companies, who say that the findings "underscore the persistent nature of obesity," comparing it to managing diseases like high blood pressure.
User Testimonies
People who have stopped the medication report a powerful return of appetite.
"It felt as if a trigger flipping and you become starving," described one woman.
The struggle is worsened if patients have not developed lasting lifestyle or habit changes during therapy.
Widespread Interest
Figures suggest that a significant number of people in the UK have used these injections in the last 12 months, with desire continuing to grow.
- Use is greater among females than men.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion access the medications through private healthcare rather than the NHS.
Ultimately, researchers emphasize that while these medications are powerful agents for weight loss, they are not a permanent cure and maintained weight loss relies on integrated lifestyle changes.
